Senescence refers to a scenario when a living being can survive all calamities but eventually dies due to causes relating to old age. Conversely, premature death can refer to a death that occurs before old age arrives, for example, human death before a person reaches the age of 75.[78] Animal and plant cells normally reproduce and function during the whole period of natural existence, but the aging process derives from the deterioration of cellular activity and the ruination of regular functioning. The aptitude of cells for gradual deterioration and mortality means that cells are naturally sentenced to stable and long-term loss of living capacities, even despite continuing metabolic reactions and viability. In the United Kingdom, for example, nine out of ten of all the deaths that occur daily relates to senescence, while around the world, it accounts for two-thirds of 150,000 deaths that take place daily.[79]
Almost all animals who survive external hazards to their biological functioning eventually die from biological aging, known in life sciences as "senescence." Some organisms experience negligible senescence, even exhibiting biological immortality. These include the jellyfish Turritopsis dohrnii,[80] the hydra, and the planarian. Unnatural causes of death include suicide and predation. Of all causes, roughly 150,000 people die around the world each day.[48] Of these, two-thirds die directly or indirectly due to senescence, but in industrialized countries – such as the United States, the United Kingdom, and Germany – the rate approaches 90% (i.e., nearly nine out of ten of all deaths are related to senescence).[48]
Physiological death is now seen as a process, more than an event: conditions once considered indicative of death are now reversible.[81] Where in the process, a dividing line is drawn between life and death depends on factors beyond the presence or absence of vital signs. In general, clinical death is neither necessary nor sufficient for a determination of legal death. A patient with working heart and lungs determined to be brain dead can be pronounced legally dead without clinical death occurring.[82]